Jen Aniston‘s smartwater is about to break.

Aniston has teamed up with smartwater again after last year’s collaboration on her first-ever “viral” video. Now the #1 premium water brand in the U.S. and the most photographed woman in the world have teamed up once again poking fun at the ever-constant gossip about Jen — “Is she pregnant? Is she engaged? How does she stay so thin? Does she really drink that much smartwater?”

The latest Aniston/smartwater video just launched and there are cameos from Ryan Seacrest and Jimmy Kimmel.

Check it out….