Even a little cold couldn’t keep Hollywood’s ‘It’ girlfriend from frowning.

George Clooney’s gal pal was spotted this week in a Los Angeles Pharmacy picking up Cold-EEZE before heading out of town to Los Cabos, Mexico with her new boyfriend.

Tongues will continue to wag though as Clooney is rumored to be finally opening up about his latest love in the upcoming issue of Rolling Stone which hits stands now.